"help" → support
"help" is the verb here. Synonyms could be "assist", "support", or "aid". So help.
Wait, "with that" is a prepositional phrase. Let me make sure the substitutions make sense. "With that" could be "about that", "regarding it", etc. So combining the two words: with that?
"With that" – "with" can be replaced with "about", "regarding", or "concerning". "That" can be "this", "it", or "the matter". So maybe about and this.
me can't help with this
"I" → three options, okay.