Receptor binding: Owls exhibit distinct receptor variants and binding strengths, which may influence drug efficacy and potency.
Antibiotics: Enrofloxacin, trimethoprim-sulfamethoxazole, and amoxicillin are commonly used to treat microbial invasions in owls. Anti-inflammatory drugs: Meloxicam and flunixin meglumine are commonly used to control discomfort and inflammation in owls. Anesthetics: Isoflurane and sevoflurane are commonly used for sedation in owls. Antiparasitics: Ivermectin and fenbendazole are commonly used to treat parasite-related infestations in owls. clinical owl pharmacology pdf
Pharmacokinetics is an examination of the temporal profile of a drug’s absorption, distribution, metabolism, and excretion. In owls, PK is shaped by their unique physiology. As an example: In owls, PK is shaped by their unique physiology
Absorption: Owls have a relatively short digestive tract, which may influence uptake of orally given drugs. Distribution: Owls have a high percentage of body fat, which may impact distribution of lipid-soluble drugs. Metabolism: Owls exhibit distinctive hepatic metabolism, characterized by elevated glucuronidation and sulfation capacity. Excretion: Owls possess a relatively reduced glomerular filtration rate, which can affect the excretion of medications. 2 : Clinical Pharmacology in Birds
References 1 : Owl Pharmacology , Journal of Veterinary Pharmacology and Therapeutics, 2020. 2 : Clinical Pharmacology in Birds , Veterinary Clinics of North America: Exotic Animal Practice, 2019. 3 : Pharmacokinetics of Enrofloxacin in Owls , Journal of Veterinary Internal Medicine, 2018.